A survey of biochemistry with a strong emphasis on the chemical logic underlying the structure, function, and evolution of biomolecules. Amino acids and protein structure, purification, and analysis. DNA, RNA, genes, and genomes. DNA replication, repair, and recombination. RNA synthesis and processing. Protein synthesis and turnover, control of gene expression. Hemoglobin. Drug development. Enzyme kinetics, catalytic and regulatory strategies. Carbohydrates. Offered as CHEM 328 and CHEM 428. Prereq: CHEM 224 or CHEM 323.