This is a project based data science research class, in which project teams identify a research project under the guidance of a domain expert professor. The research is structured as a data analysis project including the 6 steps of developing a reproducible data science project, including 1: Define the ADS question, 2: Identify, locate, and/or generate the data 3: Exploratory data analysis 4: Statistical modeling and prediction 5: Synthesizing the results in the domain context 6: Creation of reproducible research, Including code, datasets, documentation and reports. During the course special topic lectures will include Ethics, Privacy, Openness, Security, Ethics. Value. Offered as DSCI 352 and DSCI 452. Prereq: (DSCI 133 or DSCI 134 or ENGR 131 or EECS 132) and (STAT 312R or STAT 201R or SYBB 310 or PQHS/EPBI 431 or OPRE 207) and (DSCI 351 or (SYBB 311A and SYBB 311B and SYBB 311C and SYBB 311D) or SYBB 321 or MKMR 201).